Public Recommendations Only — Not Medical Advice
Public recommendations only — compiled from publicly available Huberman Lab episodes, AMAs, and interviews. Not medical advice. Not a personal prescription. Dates reflect when the statement was publicly made or published; his stack can change. Always consult your doctor before starting any supplement.
Latest public recommendation: 2024-2026
Sources span: 2023-2025 – 2024-2026
Dr. David Sinclair
Lifespan
Harvard Medical School professor and longevity researcher. Author of Lifespan and host of the Lifespan podcast.
Last updated: September 2026
Visit Dr. David Sinclair's website →Public Supplement Recommendations (8)
NMN (Nicotinamide Mononucleotide)
Strong sourceDosage: 1g daily (morning)
"Has publicly discussed taking NMN for NAD+ support and cellular energy. Part of his longevity protocol."
Note: Longevity research context; not medical advice
Vitamin D
Strong sourceDosage: 4,000-5,000 IU daily
"Recommends vitamin D supplementation as part of foundational health protocol."
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Omega-3
Strong sourceDosage: 1-2g EPA+DHA daily
"Discusses omega-3 fatty acids for cardiovascular and brain health."
Resveratrol
Strong sourceDosage: 1g daily (morning with fat)
"Long-time public advocate for resveratrol supplementation based on his research into sirtuins and longevity pathways."
Note: Research-based recommendation; verify latest stance
TMG (Trimethylglycine)
Public sourceDosage: 500mg-1g daily
"Mentioned taking TMG as a methyl donor when supplementing with NMN."
Note: Used alongside NMN for methylation support
Vitamin K2
Public sourceDosage: 100-200 mcg MK-7 daily
"Discusses vitamin K2 for cardiovascular health and calcium metabolism."
Metformin
Public sourceDosage: 1g daily (prescription)
"Has publicly discussed taking metformin off-label for longevity benefits, though not a supplement per se."
Note: Prescription medication, not OTC supplement; longevity research context
Quercetin
Older/less specificDosage: 500mg-1g (intermittent dosing)
"Has mentioned quercetin as a senolytic compound in longevity research discussions."
Note: Research context; senolytic protocol