Public Recommendations Only — Not Medical Advice

Public recommendations only — compiled from publicly available Huberman Lab episodes, AMAs, and interviews. Not medical advice. Not a personal prescription. Dates reflect when the statement was publicly made or published; his stack can change. Always consult your doctor before starting any supplement.

Recommendations from: 2020-2026 · 2022-2026 · 2020-2025

Mark Sisson

Primal Blueprint / Primal Kitchen

Former endurance athlete, author of The Primal Blueprint, and founder of Primal Kitchen. Advocates for primal/ancestral health principles.

Last updated: September 2026

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Public Supplement Recommendations (8)

Omega-3 Fish Oil

Strong source

Dosage: 2-3g EPA+DHA daily

"Long-time advocate for omega-3 supplementation as part of primal health foundation. Emphasizes EPA/DHA for inflammation balance."

Date: 2020-2026

Source: Mark's Daily Apple blog and Primal Blueprint

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Matching products in Vault:

Nordic Naturals — Ultimate Omega Fish Oil (120 Softgels)

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Vitamin D

Strong source

Dosage: 4,000-5,000 IU daily (or based on testing)

"Strong proponent of vitamin D supplementation, especially for those not getting regular sun exposure. Part of primal essentials."

Date: 2020-2026

Source: Mark's Daily Apple

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Matching products in Vault:

NOW Foods — Vitamin D3 1,000 IU

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NATURELO — Vegan Vitamin D3 2500 IU, 120 capsules

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Magnesium

Strong source

Dosage: 400-600mg before bed

"Discusses magnesium's importance for sleep, recovery, and metabolic health in primal lifestyle."

Date: 2020-2026

Source: Mark's Daily Apple

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Matching products in Vault:

NOW Foods — Magnesium Glycinate 400mg

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Probiotic

Strong source

Dosage: 10+ billion CFU daily (varied strains)

"Recommends probiotic supplementation for gut health and immune function as part of ancestral health approach."

Date: 2020-2026

Source: Primal Blueprint and Mark's Daily Apple

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Note: Check Vault for probiotic products

Creatine

Public source

Dosage: 5g daily

"Has discussed creatine monohydrate for muscle health and cognitive benefits in aging."

Date: 2022-2026

Source: Mark's Daily Apple blog posts

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Matching products in Vault:

Creapure Ingredient — Creatine Monohydrate (Creapure)

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Protein Powder

Public source

Dosage: 20-30g per serving as needed

"Discusses protein supplementation (whey or collagen) for meeting daily protein targets in primal lifestyle."

Date: 2020-2026

Source: Mark's Daily Apple and Primal Kitchen

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Note: Part of Primal Kitchen product line

Collagen

Public source

Dosage: 10-20g daily

"Advocates for collagen supplementation for joint health, skin, and connective tissue support."

Date: 2020-2026

Source: Primal Kitchen and Mark's Daily Apple

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Vitamin K2

Public source

Dosage: 100-200 mcg MK-7 daily

"Mentions vitamin K2 for bone health and calcium metabolism, especially with vitamin D supplementation."

Date: 2020-2025

Source: Mark's Daily Apple

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